Description

The Shoda Lab

As a physician-scientist bridging between the bed and bench, Dr. Shoda's mission is to improve the lives of patients with severe allergies and their families by accelerating translational research. The Shoda Lab aims to establish future precision medicine by the comprehensive, personalized characterization of genetic, molecular and clinical features of severe allergies, including eosinophilic conditions. The extent of clinical burden of eosinophilic diseases, such as severe eosinophilic asthma and eosinophilic gastrointestinal diseases (EGID), and the complexity of their disease pathogenesis are intriguing and challenging. Through translational and clinical research, the Shoda Lab at Cincinnati Children's identifies key genes and genetic regulatory mechanisms that predispose to eosinophilic conditions, especially EGID, with the goal of improving understanding, diagnosis, and treatment.

REPRESENTATIVE RESPONSIBILITIES

???Perform experiments and record data
Follow research protocol. Maintain accurate and detailed records of all laboratory work and experiments. Analyze data; perform statistical and graphical analysis of data. Design and execute daily laboratory experiments in coordination with senior laboratory personnel. Reproduces and evaluates techniques and results for accuracy. Apply standard protocols to specific experiments, research and improve current methods, and evaluate innovative techniques. Assists in training students and new/junior laboratory personnel in laboratory techniques and equipment operation.

???Lab Administration
Troubleshoot and correct erroneous results or problems with laboratory equipment. Reproduces and evaluates techniques and results for accuracy. Maintain inventory of laboratory supplies and equipment. Maintain cell cultures. Operate standard laboratory equipment. Use and maintains laboratory equipment appropriately. Responds to obviously erroneous results or problems with equipment. Assists in daily operations of the laboratory including answering phone, maintaining lab supplies, organization, and cleanliness.. Provides appropriate safety monitoring checks as assigned (radiation safety, biosafety, etc.).

???Serve as a Resource
Demonstrate competence in specific knowledge, skills and behaviors. Effectively communicate with team members and contribute to their growth by sharing knowledge, experience, and skills. Stay abreast of changes in key systems. Serve as a resource to the department in specific area(s).

???Customer Service
Maintain/manage strong working relationships with clients, colleagues, and other key stakeholders. Respond to requests quickly and effectively. Identify and understand customer needs and expectations and meets them. Communicate any relevant information to clients, colleagues, and other key stakeholders.

Current Projects

• Molecular Diagnostic Panels, Blood Biomarkers, Disease Endotypes and Mechanisms for Eosinophilic Gastrointestinal Disorders
• Combinatory Effects of Genetic Variants in Eosinophilic Esophagitis
• Characterizing the Effects of Genes/Variants Using Ex Vivo Disease Modeling Systems

Qualifications

EDUCATION/EXPERIENCE

Required for RAII:

??? High school diploma or equivalent

??? 2 years of work experience in a related job discipline. or equivalent combination of education and experience

???May require an Associate degree, vocational training, apprenticeships or equivalent

Required for RAIII:

??? Bachelor's degree in a related field

??? 1 year of work experience in a related job discipline OR Master's degree in a related field

Required for RAIV:

??? Bachelor's degree in a related field

??? 3 years of experience in related job discipline OR Master's degree and 2 years experience

Unique Skills:

We are seeking an applicant with a capacity for independent thinking, collaborative work, and problem-solving, and shows motivation and implication for the area of research. Candidates with experience in RNA biology and/or immunology with human study, cell culture techniques, molecular biology, biochemistry, developmental biology (e.g. 3D organoids), and/or microscopy are encouraged to apply.